Tuberculosis and Malaria affects over 3 billion people globally. These diseases have been largely neglected for a long time till recently. Numerous organizations are partnering to eradicate these diseases completely from the countries they still exist in. The Social Innovation in Health Initiative is an international collaboration between the Bertha Centre for Social Innovation and Entrepreneurship at the University of Cape Town, the Skoll Centre for Social Entrepreneurship at Oxford University and TDR, the Special Programme for Research and Training in Tropical Diseases, hosted at the World Health Organization in Geneva. SIHI selected Sproxil as an innovative organization creatively employing technology to tackle aspects of eradicating these tropical diseases.